If you're itching to get away from it all and have a quiet weekend, consider a (day or overnight) trip out to rural Edisto.
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Charleston Magazine has put together a nice piece on the many things the island has to offer, here's a taste:
The unhurried scenery continues on the beach side of the 68-square-mile island. The developed beachfront on Edisto is only about three miles long and includes state-park campsites in sight and earshot of ocean waves, one grocery store (a Piggly Wiggly), the beachfront Pavilion with its dance floor and Saturday-night shag lessons, and roads lined with mostly old-school beach houses. The island, just south of Kiawah and Seabrook (but so very different in style), is known to be the summer refuge of generations of family and friends who gather for long days on the porch and in the surf, and then cook up hamburgers or seafood on barbecue grills at night.